Gabantin 300: indications and contraindications, instructions for use

Gabantine is a vivid representative of antiepileptic drugs due to its high efficacy and significant safety level. In this case, the instruction on the use of Gabantine 300 indicates the possibility of using the drug for the treatment of any kinds of epileptic seizures.

A similar effect is achieved due to the interaction of the active substance with GABA receptors, which are found in large numbers on nerve cells. Before using the drug, be sure to consult your doctor.

Pharmacological action of Gabantine 300

The action of the drug is associated with the interaction of the active substance with GABA receptors located in the central nervous system. The active substance is gabapentin. Similar action is available and analogues Gabintina: valproate and barbiturates. Interaction with receptors to a given acid leads to inhibition of neuronal activity, which allows you to cope with epileptic seizures.

Gabapentin does not alter GABA metabolism, it has high specificity for these receptors, which makes it a unique drug. The effect of the active substance on intracellular calcium metabolism relieves the patient of neuropathic pain when taking the medication.

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The drug is rapidly absorbed from the gastrointestinal tract, regardless of the meal. The maximum concentration of the active substance in the blood is reached 2-3 hours after taking the medicine. Gabantine 300 is able to easily penetrate the blood-brain barrier, which is associated with its effect on the central nervous system.

Indications and contraindications

Gabantin 300 tablets are indicated for the treatment of various types of epileptic seizures, primary and secondary, associated with organic brain diseases. It is possible to effectively treat even drug-resistant forms of epilepsy in both adults and children.

It is possible to use the drug in the form of monotherapy, as well as in combination with other medications to improve the effectiveness of treatment. And also proved the effectiveness of Gabantine 300 in the therapy of neuropathic pain in patients older than 18 years.

Among the contraindications to the use of the drug, absolute contraindications and relative are distinguished. To the absolute include:

• acute pancreatitis;
• the age of the patient is less than 3 years;
• hereditary or acquired disorders of metabolism of galactose and glucose;
• individual intolerance of the constituent components of the drug or a high sensitivity to gabapentin.

Relative contraindications restrict the administration of Gabantin 300, but do not prohibit:

• , renal dysfunction, as the excretion of the drug predominantly occurs through them;
• pregnancy and lactation due to insufficient data on the effect of the active substance on the developing fetus and the baby. Therefore, the reception of Gabantine 300 is possible if the benefits for women are much greater than the potential risk to the fetus;
• elderly age is associated with a large number of complications due to the high incidence of renal impairment;
• absences and mixed epileptic seizures.

In the presence of contraindications, the attending physician decides whether to take the medicine or select analogues.

Application of Gabantine 300

The dose and multiplicity of the drug is determined by the attending physician. In no case should you yourself change the dosage of the medicine or prescribe yourself. The treatment of epilepsy with Habantine 300 depends on the patient's age:

1. If a person is under 12 years of age, the dosage is based on the weight of the child. The average therapeutic dosage is about 30 mg per one kilogram of the child's body weight. The attending physician adjusts the dose depending on the clinical symptoms. It is possible to increase the dosage to 50 mg per day per kilogram of body weight.
2. Patients older than 12 years. The starting daily dose of Gabantine 300 is about 300 mg. Over the next two days, the starting dose is increased 2 and 3 times, on the third day of treatment, the dose of the drug reaches 900 mg per day. The time between taking medication should not be more than 12 hours. The maximum daily dose of Gabantine is 3600 mg, not more than 12 capsules.

If necessary, neuropathy therapy, the starting dosage of the drug is 900 mg, three capsules of the drug three times a day. The daily allowable dose for treatment is similar - no more than 3600 mg. It is important to carefully monitor the dose of the drug in patients with kidney disease, as they have broken the excretion of drug metabolites.

Side effects and overdose

The most important point of prevention of overdose is non-compliance with the dosage indicated by the doctor in charge. Therefore, the patient should always adhere to the prescribed dose of Gabantine 300.

Symptoms of overdose are as follows: disruption of the digestive system, increased drowsiness, visual and speech impairment, various types of dizziness. If the patient develops an overdose, it is recommended to wash the stomach, take enterosorbents, contact the doctor for medical help.

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With the use of Gabantin 300, there may be various complications:

• from the side of the brain may appear dizziness, insomnia, increased mental fatigue, mood disturbances and the like;
• possible changes in blood pressure, increased heart rate, decrease in the number of leukocytes;
• from the digestive system: pain in the abdominal region, attacks of nausea, vomiting, bloating, various types of pancreatitis;
• muscle pains and joint pain.

If side effects develop, contact your doctor to adjust the dosage or cancel the drug with a choice of its analogues.

Reviews about Gabantine 300 and the price of the drug indicate its high efficiency, availability, low risk of side effects, if you follow the instructions for use. However, it is important to remember that the appointment of the drug and the selection of its dosage should be performed only by the attending physician after the examination of the patient.